250 mg tablet, 500 mg tablet, 125mg/5ml powder for suspension, 750 mg IV/IM injection

1. What Turbocef® is and what it is used for?
Turbocef® (Cefuroxime) is second generation Cephalosporin antibiotic. Cefuroxime is used to treat certain infections caused by bacteria, such as bronchitis; gonorrhea; Lyme disease; and infections of the ears, throat, sinuses, urinary tract, and skin.

2. Before you take Turbocef®
Do not take this medicine and tell your doctor if:

If you have allergy to the Cephalosporin group of Antibiotic.

Take special care with Turbocef®
Cefuroxime should be given with caution to patients receiving concurrent treatment with potent diuretics because these diuretics are suspected of adversely affecting renal function. Risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy.

Check with your doctor before taking this medicine if:
Before therapy with Cefuroxime, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to Cefuroxime products or patients with a history of penicillin allergy. Caution should be exercised because cross-hypersensitivity among beta-lactam antibiotics has been clearly documented.

Taking other medicines
Concomitant administration of probenecid with Cefuroxime increases the area under the serum concentration versus time curve by 50%. Drugs that reduce gastric acidity may result in a lower bioavailability of Cefuroxime.

Pregnancy and breast-feeding
Pregnancy Category B: Cefuroxime has not been studied for use during labor and delivery. Nursing Mothers: Because Cefuroxime is excreted in human milk, consideration should be given to discontinuing nursing temporarily during treatment with Cefuroxime.

3. How to take Turbocef®?
Taking this medicine as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

How much to take?
For Adolescents and Adults (13 years and older): 250 – 500mg twice daily for 7-10 days without regard to food.
For pediatric patient (3 months to 12 years): 20-30mg/kg/day twice daily for 10 days with food.
Injection: 750 mg to 1.5 g IM or IV every 8 hourly, usually 5 to 10 days. In case of infants and children (>3 months): 50 to 100 mg/kg/day in equally divided doses every 6 to 8 hours.

If you take more Turbocef® than you should
If you have too much of this medicine, talk to your doctor straight away.

If you forget to take Turbocef®
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

If you stop taking Turbocef®
Do not stop taking this medicine without talking to your doctor. You should not stop taking Turbocef® just because you feel better. This is because the problem may come back or get worse again.
If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, Turbocef® can cause side effects, although not everybody gets them.

Hypersensitivity reactions: Anaphylaxis, angioedema, pruritus, rash, serum sickness-like reaction, and urticaria. Gastrointestinal: Pseudomembranous colitis Hematologic: Hemolytic anemia, leucopenia, pancytopenia, and thrombocytopenia and increased prothrombin time. Skin: Erythemia multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis.

Tell your doctor if any of the side effects gets serious or lasts longer than a few days, or if you notice any side effects not listed in this leaflet.

5. How to store Turbocef®?
Tablet: Store in a cool and dry place, protected from light.
Powder for Suspension: Store in a cool place preferably in a refrigerator, protected from light & moisture.
Injection: Store below 25º C, protected from light. The reconstituted solution for IV or IM administration maintain potency for 24 hours at room temperature and for 48 hours when refrigerated at 5º C.

Turbocef Prescribing Information

Located in: Anti-infectives