1. When to take Cox B®?
- For the relief of the signs and symptoms of osteoarthritis.
- For the relief of the signs and symptoms of rheumatoid arthritis.
- For the regression and prevention of colorectal adenomatous polyps
- In patients with familial adenomatous polyposis (FAP).
2. How to take Cox B®?
- Osteoarthritis: The recommended oral dose is 200 mg per day administered as a single dose or as 100 mg twice daily.
- Rheumatoid arthritis: The recommended oral dose is 100 to 200 mg twice daily.
- Familial adenomatous polyposis (FAP): Usual medical care for FAP patients should be continued while on Cox B. To reduce the number of adenomatous colorectal polyps in patients with FAP, the recommended oral dose is 400 mg (2 x 200 mg capsules) twice daily to be taken with food.
3. Who should not take Cox B®?
Cox B is contraindicated in patients with known hypersensitivity to Celecoxib. It should not be given to patients who have demonstrated allergic type reactions to Sulphonamides (Celecoxib contains a sulphonamide side chain). Celecoxib should not be given to patients who have demonstrated asthma, urticaria or allergic type reactions after taking Aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic like reactions to NSAIDs have been reported in such patients.
4. How Cox B® works?
Cox B (Celecoxib) is a selective cyclooxygenase-2 (COX-2) inhibitor, nonsteroidal anti-inflammatory drug (NSAID). It exhibits anti-inflammatory, analgesic and antipyretic properties. The mechanism of action of Celecoxib is believed to be due to the inhibition of prostaglandin synthesis, via the inhibition of cyclooxygenase-2 (COX-2) enzyme. At therapeutic concentration, Celecoxib does not inhibit cyclooxygenase-1 (COX-1) isoenzyme.
5. How supplied?
Cox B® 100 Capsule : Box containing 50 capsules in 5 x 10′s blister strips. Each capsule contains Celecoxib INN 100 mg.
Cox B® 200 Capsule : Box containing 50 capsules in 5 x 10′s blister strips. Each capsule contains Celecoxib INN 200 mg.